How open is “open” chromatin? Our new Nature Genetics paper uses nucleosome-resolution modeling to reveal condensed euchromatin domains with short, accessible regulatory regions at the surface. www.nature.com/articles/s41...

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🧬 Our live-cell imaging also shows condensed euchromatic domains—and that cohesin prevents their local mixing, helping maintain transcriptional insulation. www.nature.com/articles/s41...

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IMO the paper of the year in the gene regulation field - such a clean and clear study, showing how promoter-enhancer contacts mediate transcriptional activation. www.cell.com/cell/abstrac...

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Combine a chemical knowledge, generative modeling, and structure prediction into a pipeline that can design enzymes for new-to-nature chemistry. @zacharywu.bsky.social @alexechu.bsky.social @francesarnold.bsky.social @pushmeet.bsky.social @juewang.bsky.social www.biorxiv.org/content/10.6...

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OpenAI’s dot is a protein designer now 😂 It runs RFdiffusion/MPNN/AF2 on its cloud computer, tracks progress in a scratchpad, and opens the predicted designs in PyMOL to click through. All on CPU. Time to enter the Anthropic × Adaptyv competition with this setup? Wish me luck 😆

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