It has been a pleasure to watch @jmella.bsky.social lead this project - a technical tour de force that brought saturation mutagenesis to cardiomyocytes for the first time, revealed CM-specific effects of LMNA mutations + new features of lamin structure and quality control.

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Extraordinary work by Jess Mella. In a technical tour de force she got over nearly 20k variants into hipscs to study the effects in an important nuclear envelope protein LMNA. She used it to dive into cell, structure, and human genetics biology. Keep an eye on her and her future is bright!

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First preprint from the lab 🚨 We asked when and how global chromatin organization emerges during early development 🐟

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Jim Shorter and his postdoc Miriam wrote a beautiful preview about our most recent paper on mRNAs preventing misfolding of IDR-containing proteins. UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins: Cell www.cell.com/cell/fulltex...

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Interested in transcriptional regulation, enhancers and 3D genome folding? In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control www.biorxiv.org/content/10.6... detailed 🧵👇

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