The 4DN Center for 3D Structure and Physics of the Genome proudly presents: "Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation". www.biorxiv.org/content/10.6...

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1\ We know a bit about how 3D chromatin interactions are formed, but what do we know about how they are disrupted? We asked this question in our latest preprint: doi.org/10.64898/202..., focusing on the massive loss of promoter interactions during neuronal differentiation.

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Our new preprint @biorxivpreprint.bsky.social, led by @katsuminami.bsky.social‬ et al.! 🎉 www.biorxiv.org/content/10.6... Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.

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Seeing this out is very rewarding. I would also like to acknowledge @bracciolilab.bsky.social, @michielvermeulen.bsky.social and @robinhweide.bsky.social and others not on BlueSky. Robin just started his own lab in Utrecht. Go check him out!

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It’s a wrap! 🎉 iDEMM 2026 is done — two days, 160 scientists, the most exciting embryo model science around. Less conference, more rock festival — just with pipettes instead of guitars. 🎸🔬 Huge thanks to speakers, posters, attendees, and my co-organizers @bracciolilab.bsky.social and Hendrik Marks.

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