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Wendy Bickmore

@wbickmor.bsky.social did:plc:llo2mkdjjxl44rv7tmoiu4pj

Scientist at University of Edinburgh. Director of MRC Human Genetics Unit but posting in my own capacity.

Bluesky’a katılma tarihi:

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3.099
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58
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86
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Özet

Wendy Bickmore (@wbickmor.bsky.social), 24 Ağustos 2024 tarihinde katılan bir Bluesky kullanıcısı. 3.099 takipçisi var, 58 hesabı takip ediyor ve 86 post paylaştı.

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Son beğendiği postlar

Bluesky ağındaki herkese açık beğeniler.

  • Cees Dekker@ceesdekker.bsky.social

    Latest #CDlab paper on BioRxiv: www.biorxiv.org/content/10.6... How do intercalators affect DNA loop extrusion by SMC proteins? Brian Analikwu found that they lower SMC binding and extrusion speed. Also, he shows a new assay without intercalators that shows loop extrusion but at twice the speed!

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  • Joe Marsh@jmarshlab.bsky.social

    New preprint: clear signs that variant effect predictors are now shaping ClinVar labels. Good for clinical use, but it creates circularity: predictors are trained, benchmarked and calibrated on labels that predictors helped create. www.biorxiv.org/content/10.6...

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  • Darío Lupiáñez@dariloops.bsky.social

    🚨Preprint from our lab🚨 How and when did TADs emerge during evolution? 🐁🐟🪰 HINT: the diversification of CTCF regulation and functions enabled new mechanisms of 3D chromatin folding 🧬 With Liene Astica & @rdacemel.bsky.social Link: www.biorxiv.org/content/10.6... Bluetorial 1/15👇

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  • Mihaly Badonyi@mbadonyi.bsky.social

    How do computational predictors compare with experimental assays (MAVEs) for variant classification? Across five hereditary cancer genes, MAVE scores were more conservative (fewer pathogenic calls) yet more decisive (fewer indeterminate calls) after ACMG/AMP calibration. doi.org/10.1186/s130...

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  • Cees Dekker@ceesdekker.bsky.social

    Our latest #CDlab paper on BioRxiv: www.biorxiv.org/content/10.6... Led by 1st author Jaco van der Torre, we report our technique to create long (100 kb) DNA molecules with entirely user-defined sequences. We use this to design motif-depleted DNA sequences for single-molecule experiments.

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