Wendy Bickmore
@wbickmor.bsky.social did:plc:llo2mkdjjxl44rv7tmoiu4pj
Scientist at University of Edinburgh. Director of MRC Human Genetics Unit but posting in my own capacity.
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Wendy Bickmore (@wbickmor.bsky.social) es un usuario de Bluesky que se unió el 24 agosto 2024. Tiene 3.099 seguidores, sigue a 58 cuentas y ha publicado 86 posts.
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Historic return of #beavers to waters around #LochNess, 500 years after they were last recorded in the area 🦫 Watch the first release of the Ness Beaver Project with @beavertrust.org as a family of six beavers takes to a lochan at @visitdundreggan.bsky.social. Read more👉 bit.ly/3WNdaq8
Ver postLatest #CDlab paper on BioRxiv: www.biorxiv.org/content/10.6... How do intercalators affect DNA loop extrusion by SMC proteins? Brian Analikwu found that they lower SMC binding and extrusion speed. Also, he shows a new assay without intercalators that shows loop extrusion but at twice the speed!
Ver postNew preprint: clear signs that variant effect predictors are now shaping ClinVar labels. Good for clinical use, but it creates circularity: predictors are trained, benchmarked and calibrated on labels that predictors helped create. www.biorxiv.org/content/10.6...
Ver post🚨Preprint from our lab🚨 How and when did TADs emerge during evolution? 🐁🐟🪰 HINT: the diversification of CTCF regulation and functions enabled new mechanisms of 3D chromatin folding 🧬 With Liene Astica & @rdacemel.bsky.social Link: www.biorxiv.org/content/10.6... Bluetorial 1/15👇
Ver postHow do computational predictors compare with experimental assays (MAVEs) for variant classification? Across five hereditary cancer genes, MAVE scores were more conservative (fewer pathogenic calls) yet more decisive (fewer indeterminate calls) after ACMG/AMP calibration. doi.org/10.1186/s130...
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