Our latest #CDlab paper on BioRxiv: www.biorxiv.org/content/10.6... Led by 1st author Jaco van der Torre, we report our technique to create long (100 kb) DNA molecules with entirely user-defined sequences. We use this to design motif-depleted DNA sequences for single-molecule experiments.

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Great to see this piece with @jmarshlab.bsky.social talking about developing a resource cataloguing computational models for predicting variant effects, what makes non-coding predictors so different from their coding counterparts, and whether VEPs will ever replace deep mutational scanning 👇🏽

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Congrats to #WGDip team members Dan Macqueen, @manukumargundappa.bsky.social & colleagues for their @natecoevo.nature.com paper, which shows that regulatory evolution following WGD was shaped by developmental & tissue-specific constraints that act across vertebrate species🐟🧪 edin.ac/4hVnxAe

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President of the Royal Society Paul Nurse responds to the Russian attack on Ukrainian Academy of Sciences: royalsociety.org/news/2026/09...

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New preprint from the lab! We used deep mutational scanning to measure the effects of nearly all amino acid substitutions in XPD/ERCC2. Our assay is strongly mechanism-selective, showing better discrimination between different disease phenotypes (TTD vs XP) than any computational predictors.

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