Yale Cell Biology

yalecellbiology.bsky.social

08 July 2026 17:31

Congratulations to @dazhi-li.bsky.social and members of the Reinisch and De Camilli groups @pdc-lab.bsky.social on their recent work on the structure of Bridge-like lipid transfer protein VPS13C!

Dazhi Li

dazhi-li.bsky.social

07 July 2026 18:57

Excited to see this study, in collaboration with the De Camilli group @pdc-lab.bsky.social, published in its final format! We resolved the structure of VPS13C and found that it adopts a lipid-transfer-incompetent conformation. We also show that CaM binds VPS13s and may help regulate their function.

Vanni Lab at UNIFR, Switzerland

labvanni.bsky.social

16 June 2026 00:31

This amazing work by @danialv.bsky.social and Bodan Hu is now out in peer-reviewed form at @cp-cell.bsky.social with a lot of new simulations! Check it out if interested in lipid transport!

Dazhi Li

dazhi-li.bsky.social

15 June 2026 15:25

Reinisch's lab work with the Vanni's lab is online in Cell!! Combining cryoEM and MD simulations, we reveal how the bridge-like lipid-transfer protein VPS13A works with the scramblase XK to deliver lipids to plasma membrane and redistribute them across the bilayer. www.cell.com/cell/fulltex...

Dazhi Li

dazhi-li.bsky.social

10 December 2025 23:17

Lipid scramblases and BLTPs are key to regulate cellular lipid dynamics. Justin Korfhage and I described in-vitro methods to study lipid scrambling by protein insertases and ATG2-mediated lipid transfer on artificial lipid droplets. www.sciencedirect.com/science/chap...