yalecellbiology.bsky.social
👤 Joined on 03 September 2025
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@yalecellbiology.bsky.socialTwo new articles from the Reinisch lab @yalecellbiology.bsky.social and De Camilli lab @yaleneuro.bsky.social provide the first complete molecular characterization of VPS13A and C, two proteins involved in neurodegenerative diseases, and show that they can exist in active and inactive states.
Show PostDon’t miss this special summer edition of the NPC/transport webinar featuring authors from our recent special @jcellsci.bsky.social issue on the Nucleus!
Show PostExcited to see this study, in collaboration with the De Camilli group @pdc-lab.bsky.social, published in its final format! We resolved the structure of VPS13C and found that it adopts a lipid-transfer-incompetent conformation. We also show that CaM binds VPS13s and may help regulate their function.
Show Post@schvartzman.bsky.social and I wrote a perspective on how dynamic metabolite-protein interactions can shape cell biology, and the open questions this raises about the broad roles of metabolism. It was fun to dig into Zabala-Letona, Carracedo et al.'s story as an example of this! tinyurl.com/4tcnrydm
Show Posthi everybody, asmita here back at it again with another preprint for your attention. excited to share our new fluorogenic speed probes that enable whole cell 3D imaging! 🔬
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