How does a single methyl group activate bacterial defence? Our new preprint, led by @pspatharas.bsky.social in collaboration with the group of @matthiaswilmanns.bsky.social, explains how a single DNA methylation event activates large retron assemblies. www.biorxiv.org/content/10.6...

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1/1 How does a single methyl group activate bacterial defence? In my PhD work with @matthiaswilmanns.bsky.social and @typaslab.bsky.social, we reveal how this tiny DNA modification triggers retron disassembly and toxin activation. Now on bioRxiv: www.biorxiv.org/content/10.6...

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New on the #cryoET Data Portal: three datasets benchmarking the crossed laser phase plate (xLPP) ⚡ Data by Reza Paraan and the @biohub.org team with collaborators at UC Berkeley. Full credits at the end of the 🧵 cryoetdataportal.czscience.com/depositions/10363

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❗Last call for applications for the @embo.org Practical Course 'In situ CLEM at room temperature and in cryo' We are excited to provide a NEW program for this 2027 edition with even MORE hands-on practicals at room temperature and in cryo ❄️ @events.embl.org

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Our latest development is now on bioRxiv: cryoSHIELDs — amphipathic peptide additives that make cryo-EM grid prep far more reliable. Tested across 24 protein systems, they enabled the first ABCC6 structure and GPCR–G protein structures at just 0.1–0.5 mg/mL! www.biorxiv.org/content/10.6...

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