How we are approaching AI at openRxiv - new blog post prompted by growing adoption by researchers, submission patterns, and questions from the community openrxiv.org/approach-to-... 1/n

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🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10

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Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇 www.nature.com/articles/s41...

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What is biology research for? "...a field grappling with AI-generated results first has to say plainly what the goals of the field’s research actually are..."

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It‘s been two years since the pre-print. In the meantime, we have been busy validating ConvexGating based gating strategies in the lab. Check out our publication at Nat Comm: www.nature.com/articles/s41...

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