Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇 www.nature.com/articles/s41...

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Not mentioned about this unethical study is "why Guinea-Bissau"? The trial is not to test efficacy - we already know it's effective - it's to test non-specific effects. There is *zero* grounds to do that in a country with high risk of HepB - if UoSD is hell-bent on doing a study, do it in Denmark.

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Fantastic news that Adele Marston will join us in 2027 as Professor of Molecular and Cellular Biochemistry at the University of Oxford. 🎉 🎉 🎉 Read the full story 👇 bit.ly/marston_10_26

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My inbox is being flooded with fully AI-generated emails from prospective students. I tried to work out why I can't bring myself to read them, and ended up with some thoughts and advice for writing cold emails in the age of AI. My new post: blekhman.substack.com/p/why-i-am-n...

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I'm not going to make this a long WTF biology thread, but just a few comments on this paper. It's about a protein implicated in the stress-adaptive plasticity of intenstinal wound healing and metastasis of colorectal cancer cells. /1 www.nature.com/articles/s41...

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