🔥Preprint alert!🔥 RNase E-dependent guide generation and activation of the SPARMA defense system Read the thread by Theo on how the short pAgo system SPARMA works, how pAgo guide RNAs are generated, and how pAgo autoimmunity is prevented. Preprint here: www.researchsquare.com/article/rs-1...

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💥 Post-doc opportunity! 💥 Come join our team (www.thelowlab.org) at Imperial, London, working on the cryo-EM structure and mechanism of bacterial secretion systems. 48 months. Please RT. For more details and to apply: www.imperial.ac.uk/jobs/search-...

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Glad my voice could contribute to this special issue of Molecular Cell on AI in molecular biology. I see a lot of promise though some perils do exist! Several other voices' opinions to read there: Ellen Zhong, Jianyi Yang, Quan Chen, Alan Wong and Judith Zaugg. www.cell.com/molecular-ce...

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Really cool work from my previous colleagues Edo and Jenia developing tools to combine cryo-volume EM and cryo-ET!

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🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...

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