romanmdoll.bsky.social
PhD Student in Medical Sciences at the University of Oxford. If it has a genome, we can do genome editing on it, right? 🧬
👤 Joined on 03 September 2023
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@romanmdoll.bsky.socialDelighted to see our latest paper out in @natgenet.nature.com ! The brilliant @jhamley98.bsky.social developed MCCv, allowing chromatin architecture to be visualised at base-pair resolution for each allele—a powerful way to identify functional genetic variants. www.nature.com/articles/s41... 🧵
Show Post1/4🧵 Really excited to see that a major part of my PhD work has now been published in Nature Genetics! 🎉 In this study, we developed Micro Capture-C variant-to-function (MCCv): a method to map how genetic variants alter gene regulation at single-allele resolution. www.nature.com/articles/s41...
Show PostToday in @nature.com we introduce INSTALL, which bypasses mammalian DNA immune sensing to enable non-viral DNA integration with recombinases—a step toward safe, and mutation-agnostic genome editing. 🧬 🧵 (1/13) www.nature.com/articles/s41... @harvardmed.bsky.social @mgbresearch.bsky.social
Show PostMake your gene knockouts more efficient with multiplexed Cas12a sgRNAs. Our new paper is out now, with tools available from @addgene.bsky.social , www.plasmids.eu and @vdrc-flies.bsky.social. www.nature.com/articles/s41... #CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰 Summary 🧵 below.
Show Post🔥Excited to share our preprint doi: doi.org/10.1101/2025... on the spatiotemporal reprogramming of the bone marrow in myelofibrosis #fibrosis #MPNsmlead in a highly collaborative effort 👇- looking forward to hearing your thoughts and please share 👍
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