The Lister Institute of Preventive Medicine

thelisterinstitute.bsky.social

16 October 2026 21:57

Great thread from Lister Fellow @jojdavies.bsky.social taking you through the findings and significance of this paper on chromatin architecture - at base-pair resolution 🫨

Jude Chander Popham

judepops.bsky.social

12 October 2026 19:35

So happy to see the core idea behind Nucleome Therapeutics published in Nature Genetics! It was a pleasure to work with MCC-inspired variant-to-function mapping platforms when I was there. Huge congrats to Joseph Hamley and I’m grateful to work with the incredible data he generated in my DPhil.

ndrdenny.bsky.social

12 October 2026 19:35

bsky.app/profile/jojd... Congrats Joe and James! Great work

James Davies

jojdavies.bsky.social

12 October 2026 19:35

Final model: The neo-CTCF site blocks super-enhancer-mediated activation of SESN3. Reduced SESN3 disrupts the SESN3–GATOR2 interaction, activating mTOR signalling and promoting immune activation.

Joe Hamley

jhamley98.bsky.social

08 October 2026 19:09

2/4 Most variants associated with common disease lie in noncoding regulatory elements, making it challenging to identify which variants are functional and which genes they dysregulate. By mapping chromatin contacts between alleles, MCCv helps assign variant function and nominate target genes.