birtehoecker.bsky.social
birtehoecker.bsky.social
Biochemist at Bayreuth University, Germany, interested in protein evolution & design
👤 Joined on 02 February 2024
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- 02 Şub 2024, 16:38
🎉 Bluesky'e katıldı - İlk kullanıcı adı:
@birtehoecker.bsky.social
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❤️ Beğendiği Gönderiler
👏 Congrats to Martin Müller, Neeraja Sudarsan, Birgit Urban, Andreas Gagsteiger, Onur Turak, Andreas Fery, and @birtehoecker.bsky.social on this interdisciplinary contribution! Funded by @dfg.de & @leibniz-gemeinschaft.de & @basfde.bsky.social
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Excited to share our latest with @birtehoecker.bsky.social: CANVAS, a de novo enzyme design strategy that builds active sites by adding tailored lids to minimal TIM barrels. Several designs reached kcat values of 13–26 s⁻¹, on par with the median natural enzyme. www.nature.com/articles/s41...
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One take-away from #benzon25 is that while we now have great structure prediction and sequence design models, many (most?) problems actually require thermodynamic models and that extracting and tuning thermodynamics from structure/sequence remains very hard.
Show PostRidiculously excited about our Benzon meeting on protein structure prediction and design that kicks off tomorrow morning #benzon25
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