Huge thanks to everyone involved. This has been a long time coming and couldn't have been done without the help of many people. @willowcoyote.bsky.social @amanglik.bsky.social @justingenglish.bsky.social @hjp.bsky.social @fraserlab.com @jingyour.bsky.social and many others not on here (10/10)

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🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10

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It took a while, but here we are. Our micDROP paper is out in @natcomms.nature.com, led by @atargt.bsky.social. She asked whether the sequence of a disordered region can self-recognize specifically. She measured this for ten IDRs in living yeast cells. www.nature.com/articles/s41...

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Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇 www.nature.com/articles/s41...

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Huge thanks to my benchmate Hojae Choi for leading this effort, Brian Coventry, Sam Pellock, Donald Hilvert, David Baker and all our coauthors! And to Luki Goldschmidt for keeping the compute infrastructure running!

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