Roberto Chica Lab
chicalab.bsky.social
Our research group at the University of Manchester specializes in computational enzyme design.
👤 Joined on 22 September 2023
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- 22 Eyl 2023, 02:08
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@chicalab.bsky.social - 10 Kas 2023, 02:49
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Great to have NIH support to learn the rules of small-molecule driven allostery in proteins! Plan is to build some pretty useful proteins along the way for biology and medicine. Interested? Reach out! And congrats to my colleague Xin! Clearly DFCI is a great place to tackle bold ideas!
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Protein Engineering: Status Report, marks the 40th anniversary of Protein Engineering, Design and Selection and provides a landmark overview of the field. Read the open access article now: academic.oup.com/peds/pages/4...
Show PostWe can design "static" binders routinely now, but design of "dynamic" shape-changing proteins has remained quite hard. Jeffrey Chang and I asked: why can't we couple small-molecule binding to shape change? After all, natural proteins do it every day. In a new preprint, we show how it can be done. 🧵
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Today out in Nature Chemical Biology @springernature.com. Thanks for great collaboration @chicalab.bsky.social
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