Jim Shaw

jimshaw.bsky.social

15 September 2026 17:54

The sylph metagenome profiler is v1.0.0! sylph-docs.github.io A new DB format + approach --> huge performance gains: GTDB-R232 (200k species) now takes < 5 GB of RAM and ~30s (2GB fq.gz). Huge thanks to @benjwoodcroft.bsky.social and his ongoing performance efforts (github.com/wwood/weebill)

PacBio

pacbio.bsky.social

26 May 2026 22:14

SPRQ-Nx chemistry is now shipping worldwide, bringing sub-$300 HiFi genomes to the Revio platform! This global rollout cuts sequencing costs by 30%, making it easier than ever to scale high-throughput workflows Full press release here: bit.ly/49HwmcL #SPRQNx #PacBio #HiFisequencing #Revio

Steven Robbins

stevenjrobbins.bsky.social

03 April 2026 18:37

That's an interesting point...again, cool stuff!

Shuai Wang

wshuai.bsky.social

03 April 2026 18:37

Hi Steven, I totally agree with Alex. In complex communities with many unknown microbes, such as soil, supervised mod calling models might have bias. In contrast, our new mod calling method is fully unsupervised, thereby avoiding such risks.

The Banfield Lab

banfieldlab.bsky.social

03 April 2026 18:36

Congratulations @wshuai.bsky.social and co-authors! We’re excited to introduce MODIFI, our new scalable method for detecting DNA modifications in PacBio metagenomic data and estimating ECE-host linkage. Check out the preprint: www.biorxiv.org/content/10.6...