nickpolizzi.bsky.social
Asst prof at HMS, PI at DFCI Designing proteins polizzilab.org
👤 Joined on 17 January 2024
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@nickpolizzi.bsky.socialNew review from the Zhang Lab in @natmethods.nature.com led by @ammgest.bsky.social ! Explore recent advances in fluorescent proteins and biosensors, including improved photostability, high-throughput screening, quantitative imaging, and multiplexing.🔬 Check it out now!👇 doi.org/10.1038/s415...
Show Post🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10
Show PostYay! Soon I'm starting my lab at the Centre for Genomic Regulation in Barcelona (@crg.eu 🌊), as a joint Independent Fellow with Andorra Research + Innovation (@andorrari.bsky.social ⛰️). www.crg.eu/en/programme...
Show PostHonored to be a Packard Fellow! This award will support our efforts to understand how glycans control immune responses and to harness this biology to engineer immunity to disease. @packardfdn.bsky.social @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social
Show PostOur AM-3 paper is out in Cell. Opioids are indispensable therapeutics, but have severe side effects. Because they are administered systemically, it is hard to dissect how they work, and to separate side effects. So we built one you can switch on and off with light. 🧵 www.cell.com/cell/abstrac...
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