Kazuhiro Maeshima

kazu-maeshima.bsky.social

14 September 2026 09:30

Thank you, Wendy! Very interesting. Our results (Fig. 7) demonstrate that global compaction of euchromatic domains did not change after cohesin loss, but they became more liquid-like, and a lot of deformation of the domains can occur (more elongated, etc.). 1/2

Kazuhiro Maeshima

kazu-maeshima.bsky.social

14 September 2026 09:30

This fits well with your data: the increased inter-probe distances could reflect deformation/elongation of a TAD rather than uniform decompaction. Hi-C data (Fig. 8a) show that short-distance contacts decrease and long-distance contacts increase after cohesin loss. Thanks for pointing this out! 2/2

Shiori Iida

shiori-iida.bsky.social

14 September 2026 09:29

Happy to share that this paper is now published in Nature Genetics! Grateful to everyone who supported this work throughout this long journey. I’m proud to see it out! www.nature.com/articles/s41...

Masa A. Shimazoe

masaashimazoe.bsky.social

14 September 2026 09:29

Our paper on euchromatin and cohesin is now published!!🙌 Euchromatin forms condensed domains, and cohesin constrains their local mixing. This organization maintains transcriptional insulation. This work was truly a team effort, and I’m grateful to everyone who contributed to it.

Kazuhiro Maeshima

kazu-maeshima.bsky.social

14 September 2026 09:29

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)