Bin Zhang

binzmit.bsky.social

19 October 2026 03:24

How open is “open” chromatin? Our new Nature Genetics paper uses nucleosome-resolution modeling to reveal condensed euchromatin domains with short, accessible regulatory regions at the surface. www.nature.com/articles/s41...

Gerlich Lab

gerlichlab.bsky.social

19 October 2026 02:01

Our latest paper is out in @embojournal.org! Chromatin compaction is a hallmark of apoptosis, but the mechanism & function of this process was unclear. We show apoptotic compaction is required to prevent fragmented DNA from spreading beyond the dying cell, and is driven by histone deacetylation.

Kazuhiro Maeshima

kazu-maeshima.bsky.social

14 October 2026 01:24

Our new paper is out @jcellsci.bsky.social 🧬✨ doi.org/10.1242/jcs.... @ynagata.bsky.social et al combined single-nucleosome imaging + Fucci probes. H2B-Halo motion stays nearly constant from G1 to G2. H3.3-Halo euchromatin nucleosomes are more mobile, but their motion also stays nearly constant.

Lennart Hilbert

lennarthilbert.bsky.social

03 October 2026 02:34

Normalization: most important part of any analysis, also the part nobody talks about. This paper, in my view, is all about appropriate normalization. Then check against “all available data”, and get one clean conclusion. Really neat! Joe Paggi @binzmit.bsky.social www.nature.com/articles/s41...

Anders Sejr Hansen

andersshansen.bsky.social

28 September 2026 14:05

Very nice new paper from Paggi, Long, Zhang using physical modeling of RCMC data to reconstruct physical structures of euchromatin at the nucleosome scale: Euchromatin forms condensed domains and E-P interactions largely occur on the surface! www.nature.com/articles/s41...