Paola A. Marignani
pmarignani.bsky.social
Scientist & Professor. MarignaniLab.com Precision Oncology/Model Systems/Signal Transduction/Single Cell Transcriptomics/AI/sometimes athlete. CDL Scientist/Business Strategist https://www.youtube.com/@PrecisionSciencePodcast ORCID: 0000-0001-8070-905X
👤 Joined on 05 October 2023
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You had to bring a bucket in those days.
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LKB1 loss suppresses estrogen, progesterone, and androgen signalling pathways, and that HLA-DRB5 is consistently downregulated across all STK11-mutated subtypes, suggesting an immune evasion component. A lot going on beyond the canonical AMPK-mTOR axis.
Show PostPreprint from marignanilab.com. LKB1 isn't just a tumour suppressor kinase with metabolic function; there's more😁. We used scRNAseq, CRISPR, patient tumours, METABRIC genomics & new mouse model to ask:what is the impact of losing LKB1 expression on breast cancer? www.biorxiv.org/content/10.6...
Show PostCUSMA negotiations, here we come. 🇲🇽🇨🇦🏳️
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