Lung Cancer Europe

lungcancereurope.bsky.social

01 October 2026 06:48

Could MRI find #lungcancer spread that CT misses? A 🆕 collagen-targeted contrast agent detected lung tumours as small as 0.6 mm & adrenal metastases as small as 0.1 mm in preclinical models of LKB1-mutant lung adenocarcinoma. Could it do the same in people? doi.org/10.1126/scia... #LCSM

Sebastiaan (Seb) Vanuytven

svanuytven.eurosky.social

21 September 2026 05:30

🧠 TMEformer: A spatial foundation model for tumor-microenvironment interactions, predicting cellular responses in silico across cancer types. 🍔 Dietary twist: High-fat diets worsen cachexia in Lkb1-mutant lung cancer via PGE₂ signaling to sensory neurons.

Lin S Kretschmer

linskretschmer.bsky.social

21 September 2026 05:30

www.sciencedirect.com/science/arti... #LKB1 #tumorsuppressor #kinase #STRAD #pseudokinase #small-moleculeactivator

TRAstonDrs

castltrastondrs.medsky.network

21 September 2026 05:30

In standard cells, metformin inhibits mitochondrial Complex I, reducing ATP production. LKB1 senses this energy stress and activates AMPK. AMPK shuts down the energy-consuming mTOR pathway,

TRAstonDrs

castltrastondrs.medsky.network

21 September 2026 05:30

When LKB1 is missing or mutated, the tumor cells cannot properly activate the canonical AMPK safety mechanism during metabolic stress pmc.ncbi.nlm.nih.gov/articles/PMC... When exposed to metformin, these cells continue trying to synthesize proteins & proliferate despite their dropping ATP levels.)