Check out our latest, just out in @MolecularCell! We reveal how common, typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive tumour-specific responses to PARP inhibitors - We propose that a similar synergy may contribute to A-T pathogenesis.

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[NEW PAPERs] Parallel studies from Ochs/Blackford + collaborators, including Antony Oliver from the GDSC [in Cell] - and Durocher + collaborators [in Mol. Cell] describing the role of DDIAS in binding and protecting single-stranded DNA during mitosis. doi.org/10.1016/j.ce..., doi.org/10.1016/j.mo...

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I remember reading this on bioRxiv last year. Awesome work! It’s great to see it now published in the high-impact journal it deserves. Huge congratulations to all the authors! 🎉

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Make sure to check out the exciting paper of @andrewblackford.bsky.social @fenaochs.bsky.social @profstewartlab.bsky.social et al. who also describe the identification of DDIAS, its role in the CIP2A pathway, and DDIAS/CIP2A mutations in neurodevelopmental disorders www.cell.com/cell/fulltex...

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Supremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...

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