RESEARCH PAPER: Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities By Jayachandran et al. and Petr Cejka ➡️ https://genesdev.cshlp.org/content/40/19-20/1747.abstract Petr Cejka Institute for Research in Biomedicine Università della Svizzera italiana #DNA

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Our latest paper is out in @embojournal.org! Chromatin compaction is a hallmark of apoptosis, but the mechanism & function of this process was unclear. We show apoptotic compaction is required to prevent fragmented DNA from spreading beyond the dying cell, and is driven by histone deacetylation.

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The quest to identify genetic susceptibility to breast cancer continues - of 33 clinically identified RAD51C variants, several have intermediate homologous recombination deficiencies, and some have distinct therapeutic vulnerabilities. New in NAR Cancer: academic.oup.com/narcancer/ar...

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Very pleased to share this new study: In a truly collaborative effort with the lab of Pim Huis in 't Veld @huis.bsky.social, we combined biochemistry with cell biological and genomic approaches to uncover how CIP2A works in mitotic DNA repair. www.biorxiv.org/content/10.6...

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We took Joshua Woodward's excellent cGAMP FRET reporter and adapted it for use in microscopy, with some resultant extra performance improvements. This updated tool can be used in microscopy, flow-cytometry and biochemical assays. www.nature.com/articles/s41...

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