Andrew Blackford
@andrewblackford.bsky.social did:plc:7hf6kbzafr7afbbtuko2vnex
Associate professor and CRUK Senior Fellow, University of Copenhagen and University of Oxford. My lab researches how DNA repair defects and loss of genome stability cause disease, including cancer. https://icmm.ku.dk/english/research-groups/blackford-group
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Andrew Blackford (@andrewblackford.bsky.social), 13 Kasım 2024 tarihinde katılan bir Bluesky kullanıcısı. 971 takipçisi var, 496 hesabı takip ediyor ve 34 post paylaştı.
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Check out our latest, just out in @MolecularCell! We reveal how common, typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive tumour-specific responses to PARP inhibitors - We propose that a similar synergy may contribute to A-T pathogenesis.
Postu göster[NEW PAPERs] Parallel studies from Ochs/Blackford + collaborators, including Antony Oliver from the GDSC [in Cell] - and Durocher + collaborators [in Mol. Cell] describing the role of DDIAS in binding and protecting single-stranded DNA during mitosis. doi.org/10.1016/j.ce..., doi.org/10.1016/j.mo...
Postu gösterI remember reading this on bioRxiv last year. Awesome work! It’s great to see it now published in the high-impact journal it deserves. Huge congratulations to all the authors! 🎉
Postu gösterMake sure to check out the exciting paper of @andrewblackford.bsky.social @fenaochs.bsky.social @profstewartlab.bsky.social et al. who also describe the identification of DDIAS, its role in the CIP2A pathway, and DDIAS/CIP2A mutations in neurodevelopmental disorders www.cell.com/cell/fulltex...
Postu gösterSupremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...
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