Andrew Blackford
@andrewblackford.bsky.social did:plc:7hf6kbzafr7afbbtuko2vnex
Associate professor and CRUK Senior Fellow, University of Copenhagen and University of Oxford. My lab researches how DNA repair defects and loss of genome stability cause disease, including cancer. https://icmm.ku.dk/english/research-groups/blackford-group
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Andrew Blackford (@andrewblackford.bsky.social) est sur Bluesky depuis le 13 novembre 2024. Le compte a 971 abonnés, suit 496 comptes et a publié 34 posts.
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Check out our latest, just out in @MolecularCell! We reveal how common, typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive tumour-specific responses to PARP inhibitors - We propose that a similar synergy may contribute to A-T pathogenesis.
Voir le post[NEW PAPERs] Parallel studies from Ochs/Blackford + collaborators, including Antony Oliver from the GDSC [in Cell] - and Durocher + collaborators [in Mol. Cell] describing the role of DDIAS in binding and protecting single-stranded DNA during mitosis. doi.org/10.1016/j.ce..., doi.org/10.1016/j.mo...
Voir le postI remember reading this on bioRxiv last year. Awesome work! It’s great to see it now published in the high-impact journal it deserves. Huge congratulations to all the authors! 🎉
Voir le postMake sure to check out the exciting paper of @andrewblackford.bsky.social @fenaochs.bsky.social @profstewartlab.bsky.social et al. who also describe the identification of DDIAS, its role in the CIP2A pathway, and DDIAS/CIP2A mutations in neurodevelopmental disorders www.cell.com/cell/fulltex...
Voir le postSupremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...
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