Tami Gjorgjieva
@tamigj.bsky.social did:plc:iybc6vqecl7ojm5poalj7fmn
Complex trait genetics, ethics and society, global research capacity building 🧬 🌍 ⚖️ PhD candidate with the Pritchard Lab @Stanford
Sur Bluesky depuis le
- Abonnés
- 185
- Abonnements
- 194
- Posts
- 15
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Résumé
Tami Gjorgjieva (@tamigj.bsky.social) est sur Bluesky depuis le 6 novembre 2023. Le compte a 185 abonnés, suit 194 comptes et a publié 15 posts.
Présence dans les classements
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J’aime publics du réseau Bluesky.
Excited to share my review article on the human mutation rate in a special Curr Opin Genet Dev issue on Genetics of the Human Origin: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... Fun to reflect on what's changed 10 years after @aylwyn-scally.bsky.social 's mutation rate review in the same venue
Voir le post1/7 I’m excited to share the our website for STATE OF THE ARG seminar, an online seminar series on advances in computational population genomics, with a focus on Ancestral Recombination Graphs (ARGs). Please repost and share! yundeng98.github.io/state-of-the...
Voir le postWe also show that LD tagging can cause this type of sign problem under simulation – coregulation (correlation of eQTL effect sizes across tissues) can indeed recapitulate the false sign problem that we describe in the paper.
Voir le postWe tested a recent representative TWAS model that accounts for more forms of genetic confounding (cTWAS), and found that the false sign problem persists even when we model all tissues simultaneously.
Voir le postOne takeaway after adding some new simulations is that increasingly stringent colocalization thresholds decreased false sign problems across all simulated genetic architectures, suggesting that this can help increase confidence for a focal TWAS association.
Voir le post
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