Tami Gjorgjieva
@tamigj.bsky.social did:plc:iybc6vqecl7ojm5poalj7fmn
Complex trait genetics, ethics and society, global research capacity building 🧬 🌍 ⚖️ PhD candidate with the Pritchard Lab @Stanford
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Tami Gjorgjieva (@tamigj.bsky.social) es un usuario de Bluesky que se unió el 6 noviembre 2023. Tiene 185 seguidores, sigue a 194 cuentas y ha publicado 15 posts.
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1/7 I’m excited to share the our website for STATE OF THE ARG seminar, an online seminar series on advances in computational population genomics, with a focus on Ancestral Recombination Graphs (ARGs). Please repost and share! yundeng98.github.io/state-of-the...
Ver postWe also show that LD tagging can cause this type of sign problem under simulation – coregulation (correlation of eQTL effect sizes across tissues) can indeed recapitulate the false sign problem that we describe in the paper.
Ver postWe tested a recent representative TWAS model that accounts for more forms of genetic confounding (cTWAS), and found that the false sign problem persists even when we model all tissues simultaneously.
Ver postOne takeaway after adding some new simulations is that increasingly stringent colocalization thresholds decreased false sign problems across all simulated genetic architectures, suggesting that this can help increase confidence for a focal TWAS association.
Ver postSee our previous thread on the pre-print for details on the main story: bsky.app/profile/nikh...
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