Jack Kucinski
@jackkucinski.bsky.social did:plc:e4uludrdnyuseezqrkexwgec
Ph.D. Candidate at The Ohio State University and Nationwide Children’s Hospital
En Bluesky desde el
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Resumen
Jack Kucinski (@jackkucinski.bsky.social) es un usuario de Bluesky que se unió el 22 julio 2025. Tiene 44 seguidores, sigue a 61 cuentas y ha publicado 5 posts.
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Thanks to research-driven treatment advances, 85% of children with cancer are expected to live five years or more after their diagnosis. Learn about the challenges faced by childhood and AYA cancer survivors in the AACR #CancerProgressReport: buff.ly/W80bxyH
Ver postThank you to our collaborators - what a fantastic team. And we are incredibly grateful to our funders, including the NIH/NCI, Alex’s Lemonade Stand Foundation, the V Foundation for Cancer Research, St Baldrick’s Foundation, American Cancer Society, and CancerFree Kids for supporting our research.🎗️💛
Ver postWe summarized our findings in this illustration (Credit: Mandy Root-Thompson) depicting zebrafish models to understand the fusion oncogene’s earliest activities, including invading closed DNA (TAAT wrapped around pebbles) or open DNA (GATTACA in plants) to activate neural programs.
Ver postWe found that PAX3::FOXO1 invades inaccessible chromatin and induces neural programs as one of its earliest activities. We hope to leverage these new models to find actionable targets for children with rhabdomyosarcoma.
Ver postThese studies were led by graduate students @jackkucinski.bsky.social and Alexi Tallan as part of their dissertation research. We wanted to understand how PAX3::FOXO1 initially interfaces with #chromatin in vivo and developed a new #zebrafish model and analytical pipeline to do so.
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