American Association for Cancer Research (AACR)

theaacr.bsky.social

27 August 2025 21:39

Thanks to research-driven treatment advances, 85% of children with cancer are expected to live five years or more after their diagnosis. Learn about the challenges faced by childhood and AYA cancer survivors in the AACR #CancerProgressReport: buff.ly/W80bxyH

Genevieve Kendall, PhD

kendalllab.bsky.social

25 July 2025 22:04

Thank you to our collaborators - what a fantastic team. And we are incredibly grateful to our funders, including the NIH/NCI, Alex’s Lemonade Stand Foundation, the V Foundation for Cancer Research, St Baldrick’s Foundation, American Cancer Society, and CancerFree Kids for supporting our research.🎗️💛

Genevieve Kendall, PhD

kendalllab.bsky.social

25 July 2025 22:04

We summarized our findings in this illustration (Credit: Mandy Root-Thompson) depicting zebrafish models to understand the fusion oncogene’s earliest activities, including invading closed DNA (TAAT wrapped around pebbles) or open DNA (GATTACA in plants) to activate neural programs.

Genevieve Kendall, PhD

kendalllab.bsky.social

25 July 2025 22:04

We found that PAX3::FOXO1 invades inaccessible chromatin and induces neural programs as one of its earliest activities. We hope to leverage these new models to find actionable targets for children with rhabdomyosarcoma.

Genevieve Kendall, PhD

kendalllab.bsky.social

25 July 2025 22:04

These studies were led by graduate students @jackkucinski.bsky.social and Alexi Tallan as part of their dissertation research. We wanted to understand how PAX3::FOXO1 initially interfaces with #chromatin in vivo and developed a new #zebrafish model and analytical pipeline to do so.