Jack Kucinski
@jackkucinski.bsky.social did:plc:e4uludrdnyuseezqrkexwgec
Ph.D. Candidate at The Ohio State University and Nationwide Children’s Hospital
Bei Bluesky seit
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Zusammenfassung
Jack Kucinski (@jackkucinski.bsky.social) ist seit 22 Juli 2025 auf Bluesky. Das Konto hat 44 Follower, folgt 61 Konten und hat 5 Posts veröffentlicht.
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Thanks to research-driven treatment advances, 85% of children with cancer are expected to live five years or more after their diagnosis. Learn about the challenges faced by childhood and AYA cancer survivors in the AACR #CancerProgressReport: buff.ly/W80bxyH
Post anzeigenThank you to our collaborators - what a fantastic team. And we are incredibly grateful to our funders, including the NIH/NCI, Alex’s Lemonade Stand Foundation, the V Foundation for Cancer Research, St Baldrick’s Foundation, American Cancer Society, and CancerFree Kids for supporting our research.🎗️💛
Post anzeigenWe summarized our findings in this illustration (Credit: Mandy Root-Thompson) depicting zebrafish models to understand the fusion oncogene’s earliest activities, including invading closed DNA (TAAT wrapped around pebbles) or open DNA (GATTACA in plants) to activate neural programs.
Post anzeigenWe found that PAX3::FOXO1 invades inaccessible chromatin and induces neural programs as one of its earliest activities. We hope to leverage these new models to find actionable targets for children with rhabdomyosarcoma.
Post anzeigenThese studies were led by graduate students @jackkucinski.bsky.social and Alexi Tallan as part of their dissertation research. We wanted to understand how PAX3::FOXO1 initially interfaces with #chromatin in vivo and developed a new #zebrafish model and analytical pipeline to do so.
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