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Dave Curtis

@davecurtis314.bsky.social did:plc:5txqv5mf3ggbqvulrp5672ss

Human genetics research at the UCL Genetics Institute, retired psychiatrist. Publications here: https://scholar.google.co.uk/citations?hl=en&user=Vrr4Ig0AAAAJ&view_op=list_works&sortby=pubdate

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Dave Curtis (@davecurtis314.bsky.social) es un usuario de Bluesky que se unió el 13 septiembre 2023. Tiene 474 seguidores, sigue a 78 cuentas y ha publicado 79 posts.

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  • Michel Nivard@michelnivard.bsky.social

    Interesting, I wonder whether like rare coding variants it would be worth trying to infer consequential compound heterozygous variants by there absence or depletion in UKB. Map pairs that co-occur significantly less then chance without even considering phenotype.

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  • Tyler Kent@tylervkent.bsky.social

    wasn't prepared to be emotionally wrecked by an abstract yet here we are

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  • Eric Turkheimer@ent3c.bsky.social

    I remember the first time I heard about this study a few years ago. "Uh oh, everyone thought, here comes the big genetic explanations of SES differences!" Then they finally did it, and there is essentially nothing there. /2

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  • Eric Turkheimer@ent3c.bsky.social

    But you would never know that from a casual reading of this and many similar GWAS of behavioral genotypes. They still breathlessly announce "insights." Here is the insight: genetics are a relatively unimportant factor in income theoretically (h^2) and irrelevant practically (PGS). /3

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  • Eiko Fried@eikofried.bsky.social

    This raises doubts about the many prior studies using similar data and models to recover in-credible accuracies in very small samples.

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