Agata Stepien
@agatakstepien.bsky.social did:plc:vtxob4sbbxulpxgfoaec6jnh
Transcription and RNA processing; postdoc in @stoplab.bsky.social group @uam-ibmib.bsky.social
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Zusammenfassung
Agata Stepien (@agatakstepien.bsky.social) ist seit 17 Juli 2025 auf Bluesky. Das Konto hat 55 Follower, folgt 88 Konten und hat 17 Posts veröffentlicht.
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How do our cells know where to stop transcription? 🧬 In a new Forum article in Trends in Genetics, researchers from the Kamieniarz-Gdula lab (@stoplab.bsky.social) review global evidence showing that RNA cleavage & transcription termination don't always move in sync! doi.org/10.1016/j.ti...
Post anzeigen2. Interestingly, another clue lies in the cleavage-termination distance, which is particularly short in primary tumors, especially at oncogenes. The shorter the distance, the higher the nuclear gene expression. This relationship also holds in cervical and pancreatic cancer cells.
Post anzeigen1. And the differences don’t end there! We also observed contrasting patterns of alternative polyadenylation and transcription termination during colorectal cancer progression. Remarkably, metastatic cells partially revert toward the termination patterns seen in healthy cells.
Post anzeigen3. Cleavage-termination distance is also linked to sensitivity to changes in #PCF11 and #CPSF73 levels. Could this differential dependence on pre-mRNA 3'end processing and termination factors reveal an overlooked vulnerability in tumor cells and open new avenues for cancer therapy?
Post anzeigen4. Finally, congratulations and a big thank you to @stoplab.bsky.social, @agatakstepien.bsky.social, Martyna Plens-Gałąska, Magda Kopczyńska, Kaludia Ostatek, Mariia Kapeliukha, Shazia Irshad, Hiroshi Kimura, Michal and Stephan Hamperl for their great collaboration on this project.
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