brianhie.bsky.social
AI for biology | Stanford and Arc Institute
👤 Joined on 02 October 2023
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@brianhie.bsky.socialA genome language model reveals the interactions hidden in non-coding DNA, pointing to new putative RNAs and repetitive elements in bacterial genomes. @garykbrixi.bsky.social @maxewilkinson.bsky.social @mfgrp.bsky.social @brianhie.bsky.social www.biorxiv.org/content/10.6...
Show PostProteinDPO: a protein language model for stability prediction and generation of thermostable protein sequences. @brianhie.bsky.social www.nature.com/articles/s41...
Show PostThe same method that teaches an LLM which answers people prefer can teach a protein model which sequences are more stable. This is the basis for ProteinDPO, developed by Innovation Investigator @brianhie.bsky.social, Talal Widatalla, and team.
Show PostUsing AI, researchers have designed complete, functional bacteriophage genomes from scratch and tested them against bacteria that had evolved resistance to a natural bacteriophage. Learn more in Science: https://scim.ag/45l86KH
Show Post@science.org Generative design of bacteriophages with genome language models | Science www.science.org/doi/10.1126/...
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