If you’d like to purify and analyse micronuclei quickly and easily please take a look at our new method from @jovannamaharaj.bsky.social

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In 2002, success rate at the ERC starting grant was 14%. This already felt too low to both panel and applicants, but was constrained by government funding. Well, 5 years later, it is now projected to be 5%. This is not sustainable.

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DNA can remember cancer-causing exposures long after they end. Could reading those records in at-risk populations strengthen epidemiology, uncover overlooked causes of cancer—and help prevent it? We explored the promise—and missing pieces—of mutational epidemiology earlier this year

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New paper: doi.org/10.1371/jour... Why do hypermutant cancers have atypical 'weaker' driver mutations? Modelling clonal dynamics, shows that accelerated mutation rates and biases explain this enrichment in MMRd/POLEd colorectal cancers, shifting expected genotypes.

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Did you ever want to sequence that one interesting cell you observed in your microscopy experiment? We have a new pre-print out today that describes a genetic barcoding method, Waldo, to perform live-cell imaging and single-cell sequencing on the same single cells. www.biorxiv.org/content/10.6...

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