mcclellandlab.bsky.social
Investigating origins and vulnerabilities of cancer chromosomal instability at the Barts Cancer Institute, London UK. Www.Mcclellandlab.com
👤 Joined on 09 September 2024
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@mcclellandlab.bsky.socialExcited to share the pre-print of my PhD work on purifying & sequencing micronuclei :) www.biorxiv.org/content/10.6...
Show PostRead here to learn about the fate of cancer cells whose extrachromosomal DNA gets sequestered into micronuclei. Grateful to contribute to this exciting work!
Show PostWe use a novel, kit-based method to rapidly purify MN from cell lines and tumor samples, allowing for direct sequencing of their contents to show different biases depending on the CIN landscape in each sample
Show PostOne of the first things I was taught as a youngster when contributing to hefty papers was that it's not about convincing the critical reviewer, but wearing them out. A war of attrition packed into endless polite sentences, additional analyses and distractions masking as triangulation 😐
Show PostSupremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...
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