Max Loh, PhD
basedownloh.bsky.social
scientist at small | former old school electrophysiologist at RFUMS | dopamine encoding of rewarding and aversive taste stimuli | UIC postdoc in the Roitman Lab
👤 Joined on 16 November 2024
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- 16 Kas 2024, 16:27
🎉 Bluesky'e katıldı - İlk kullanıcı adı:
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As new sensors are developed, we hope we and others will validate them in vivo and with multiple drugs challenges. We hope that the analyses used here will contribute to that process. 4/5
Show PostWhole session stream analysis also revealed differences. Most striking is the increase in mean absolute deviation with GCaMP6f and dLight1.3b, but decrease with GRABDA2h. Coupled with an overall increase in mean signal in GRABDA2h, the pattern potentially reflects sensor saturation. 3/5
Show PostWhile all sensors detected spontaneous transients during control sessions and baseline periods, their performance diverged substantially following acute morphine treatment. Morphine increased frequency and amplitude with GCaMP6f and dLight1.3b, but decreased frequency and amplitude with GRABDA2h 2/5
Show Post🚨New paper alert: Excited to share our journey to contrast how multiple dopamine sensors respond to acute morphine treatment. We first compared changes in dopamine transients in rats prepared with VTA DA GCaMP6f, NAcLS dLight1.3b or GRABDA2h 1/5
Show PostThe full publication is available at: www.sciencedirect.com/science/arti... @jamiedroitman.bsky.social @mitchroitman.bsky.social @basedownloh.bsky.social
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