xuebingwu.bsky.social
Herbert Irving Assistant Professor @ Columbia University - Genome, RNA, CRISPR, ribosome - alum: MIT | Whitehead | Tsinghua xwulab.org
👤 Joined on 19 September 2023
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@xuebingwu.bsky.socialExcited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
Show PostThis is the first of multiple manuscripts that use our patented approach to increase protein production in gene specific way from a wild type allele in happloinsufficiencies using antisense oligonucleotides. Collaboration with Tim Miller lab. www.biorxiv.org/content/10.6...
Show Post"The selfish ribosome" paper is now published in @plosbiology.org . Have a look! Many thanks to the editors and reviewers! doi.org/10.1371/jour...
Show PostSuper excited that our two companion papers on saturation genome editing (SGE) of RNU4-2 and discovery of a novel recessive neurodevelopmental disorder (NDD) were published yesterday 🥳 SGE experiment: www.nature.com/articles/s41... Recessive NDD characterisation: www.nature.com/articles/s41... 🧵
Show PostHuman DHX29 detects nonoptimal codon usage to regulate mRNA stability | @science.org www.science.org/doi/10.1126/...
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