Luis E. Valentin-Alvarado

luisvalentin.bsky.social

10 October 2026 04:07

Excited to share our work on bacterial immune signaling! Our preprint reveals how RNA-guided Cas13 cleaves host tRNAs to generate small-molecule messengers that activate 2TMβ, linking RNA recognition to membrane damage and phage defense. 1/11

Doudna Lab

doudna-lab.bsky.social

19 September 2026 04:34

Thank you @jpkbravo.bsky.social for the perspective article on our work: www.science.org/doi/10.1126/...

Doudna Lab

doudna-lab.bsky.social

19 September 2026 04:33

Out now in Science: Two papers from our lab reveal VIPR, an RNA-guided DNA-targeting system in bacteriophages, providing clues to the origins of CRISPR www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... Congrats to Peter Yoon, @kenjmloi.bsky.social @terryzzy.bsky.social, T.Docter & team

Kenneth Loi

kenjmloi.bsky.social

28 July 2026 06:58

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

Doudna Lab

doudna-lab.bsky.social

16 July 2026 21:18

Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!