grothlab.bsky.social
The Anja Groth group in Copenhagen studies chromatin replication, epigenetic memory and (epi)genome stability in the context of mitotic cell division
👤 Joined on 18 November 2024
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@grothlab.bsky.socialNext week's lab journal club paper!
Show Post🧬 How is MCM2-7 switched on? Our paper shows DDK phosphorylation exposes Sld3-binding sites on Mcm4/Mcm6. Sld3-Cdc45 then delivers Cdc45 to Mcm2/Mcm5, driving CMG assembly. In summary, our work explains why MCM2-7 phosphorylation is needed to turn on replication. www.nature.com/articles/s41...
Show PostJIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
Show PostDelighted to have been awarded a Laboratory Efficiency Assessment Framework (LEAF) Gold certification at Danish Cancer Institute (DCI). Sustainability is an integrated part of how we run the lab, reducing environmental impact without compromising research excellence.
Show PostVery cool study uncovering how stem cells pass on imprints to progeny in vivo from. @thefuchslab.bsky.social @danapeer.bsky.social drawing from beautiful work done by @grothlab.bsky.social on epigenetic inheritance and the mechanisms of information transfer through cell division.
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