Pierre-Luc Germain
plger.bsky.social
Computational biologist with a background in history&philosophy of science, working on (single-cell) RNA-seq and ATAC-seq especially in the context of stress- and activity-dependent regulation in the brain.
👤 Joined on 05 June 2026
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- 05 Haz 2026, 10:55
🎉 Bluesky'e katıldı - İlk kullanıcı adı:
@plger.bsky.social
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Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22
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That's exciting. From a hackathon in December 2023 (spatialhackathon.github.io/past.html) to a preprint in June 2025 (www.biorxiv.org/content/10.1...) to this publication out today (doi.org/10.1038/s415...).
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For anyone interested in transcription factor binding, this is a great new preprint from @plger.bsky.social. It covers questions such as - where do TFs actually bind? - what features predict their binding? - do TFs bind uniquely or do they bind to common locations?
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