maltegersch.bsky.social
Chemical Biologist & Professor at the Research Center One Health Ruhr, Essen, University of Duisburg-Essen. Interested in DUBs, proteases, ubiquitin signalling, the outdoors and more. Views are my own. https://www.uni-due.de/zmb/members/malte-gersch.php
👤 Joined on 13 November 2024
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@maltegersch.bsky.socialExcited to highlight our latest bioRxiv led by grad student Zoe Duong and Qian Shao. We report a chemistry-centric, chemoproteomics-enabled strategy to discover non-degradative molecular glues for transcriptional rewiring. 🔗 www.biorxiv.org/content/10.6...
Show PostSo proud of the lab for its achievements - Thank you to the Pettenkofer foundation for recognising our contributions - here’s to some more bacterial effector related fun in the future! @dunnschool.bsky.social
Show PostFinally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Show PostFrom degradation to stabilisation! Reprogramming the VHL-degrader CM11 into VHL-stabilisers through linker design, locking a non-ubiquitinable ternary complex. 🔗https://www.biorxiv.org/content/10.1101/2025.11.18.689129v1.full.pdf
Show PostVery happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
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