Charles Brenner, PhD
charlesmbrenner.bsky.social
NAD metabolism truth in science
👤 Joined on 06 July 2023
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- 06 Tem 2023, 23:59
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@charlesmbrenner.bsky.social - 13 Kas 2023, 00:19
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we also see an integrated stress response in the mouse model of this dz, which looks to exascerbate urea cycle function, & GWAS signal suggesting that SLC25A13 carriers have elevated FGF21 tx to all authors, funding agencies, Dr. Saheki & @citrinfdn for inspiration & support🙏
Show Postheading to helsinki to join @keisakamoto.bsky.social @awartiovaara.bsky.social and others at tuesday's SWAN meeting: healthy aging, mitochondrial disease, MASLD, rare disease and more!
Show Postour diagrams create a framework for solving the paradoxes of FGF21 (eg both ketogenic diet & simple carbs turn it on)... converging on G3P-ChREBP as the activator
Show Postthank you, Christian thanks to @russgoodman.bsky.social @markhermanmd.bsky.social @cnspracklen.bsky.social Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others
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RESEARCH | @charlesmbrenner.bsky.social et al @cityofhope.bsky.social In citrin deficiency, accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction🧪
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