Daan C. Swarts

dcswarts.bsky.social

21 October 2026 12:52

🔥Preprint alert!🔥 RNase E-dependent guide generation and activation of the SPARMA defense system Read the thread by Theo on how the short pAgo system SPARMA works, how pAgo guide RNAs are generated, and how pAgo autoimmunity is prevented. Preprint here: www.researchsquare.com/article/rs-1...

Jack Bravo

jpkbravo.bsky.social

20 October 2026 13:11

Excited to share this one, led by Theo and my postdoc Bel! We uncover how RNase E generates pAgo guide RNAs and how SPARMA turns that recognition into defense. We solved the cryo-EM structures in the Bravo lab. Great collaboration with Swarts & Zaremba! 🧬 www.researchsquare.com/article/rs-1...

Jack Bravo

jpkbravo.bsky.social

20 October 2026 13:10

Excited to share this work from our group, together with the Jackson and Beisel labs! 🧬 We found that aminoacylated tRNA fragments can act as signals to activate bacterial immunity, boosting protection by Cas12a3. Very cool biology, and a great collaboration! www.biorxiv.org/content/10.6...

Matt Barber

biobarber.bsky.social

20 October 2026 00:58

🚨 Our department is hiring! Looking to fill an endowed position in genetics/genomics to join us in beautiful Oregon. Search is at the Associate/Full Professor level. See below for details and share with your colleagues!

Luis E. Valentin-Alvarado

luisvalentin.bsky.social

10 October 2026 19:48

Excited to share our work on bacterial immune signaling! Our preprint reveals how RNA-guided Cas13 cleaves host tRNAs to generate small-molecule messengers that activate 2TMβ, linking RNA recognition to membrane damage and phage defense. 1/11