Our work out today in @nature.com! We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects. We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.

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Our plus/minus cryo-tide CDK11-cyclin L-SAP30BP #cryoEM reconstructions are now publicly available: www.emdataresource.org/EMD-59987 www.emdataresource.org/EMD-59992

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What happens when we pair HIV-1 and HTLV-1 CA subdomains in vitro? A new preprint by Mathias Percipalle from our lab provides an answer: Retroviral CA subdomains encode their immature assembly properties independently of strict subdomain co-pairing doi.org/10.64898/202... 👀Take a look!👀

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Join the wwPDB Foundation for a PDB55 celebration replay of the IUCr Plenary Presentation from Cynthia Wolberger (Johns Hopkins) on Tues Oct 20 at 3pm ET From mechanism to inhibitors: Controlling deubiquitinating enzymes in cells

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🎥 Recordings from the recent Wellcome-MRC In Situ Cryo-ET Course 2026 are now available on YouTube! From sample preparation and cryo-FIB milling to data collection, image processing and STA, check it out here: www.youtube.com/playlist?lis... #CryoET #CryoEM #StructuralBiology #eBIC #Microscopy

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