Excited to share our new research on Progranulin (PGRN) and frontotemporal dementia (FTD). We made specific antibodies to each human Granulin and find they are decreased in GRN-FTD. Supporting the idea that Granulins made in the lysosome are essential for neuronal health to stop neurodegeneration.

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It seems like we might have some news. Cats out of the bag ...

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New TYP lab paper out today in @pnas.org from former PhD student Zach Augur and postdoc @garrettfogo.bsky.social all about how astrocytic BAG3 coordinates Alzheimer's proteostasis proteins! Read all about it here: www.pnas.org/doi/10.1073/...

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I made SpliceCraft a Claude Skill! Waiting on the manual review but should be live real soon. For anyone not using Claude, I made agent side-doors that give agents full access to all the functions of SpliceCraft directly. Powerful cloning tool, deeply vetted, and made with love💚

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ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...

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