Furukawa Lab @CSHL

lab-furukawa.bsky.social

29 October 2025 20:08

How are NMDA receptor channel conductance states regulated? We uncover a mechanism for tuning ion flow and reveal striking diversity in neurosteroid binding. Our structures captured two distinct open-channel states. A fantastic collaboration with the Traynelis lab. www.nature.com/articles/s41...

Claus Wilke

clauswilke.com

07 October 2025 22:52

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon. blog.genesmindsmachines.com/p/we-still-c...

Kilian Schober

kischober.bsky.social

04 October 2025 12:25

If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

David A Knowles

davidaknowles.bsky.social

20 August 2025 22:14

Shiny new probabilistic model, gruyere 🧀, for powering up rare variant associations w/ DL effect prediction! We find novel associations for Alzheimer's disease, e.g. nuclear pore protein NUP93 in microglia. Big thanks to NIH/NIA/ADSP and Anjali for the hard work! authors.elsevier.com/a/1ldzwgeXDzHj

Tobias Marschall

tobiasmar.bsky.social

20 August 2025 22:13

Two papers in today's issue of @nature.com ‬: 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.