LoL-align is out in @natmethods.nature.com! It aligns protein structures without superposition. More sensitive than TM-align and DALI, producing better alignments 5–20× faster. Now available in Foldseek! 📄 www.nature.com/articles/s41... 💾 github.com/steineggerlab/foldseek 🌐 search.foldseek.com

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HyPhy is getting an upgrade to sleek, clean, modern C++-20 code and all kinds of other things. Much faster, cleaner, and more robust. Cool terminal output too! See github.com/veg/hyphy-3 (much more to come with VERY exciting new developments).

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This study out in @genomebiolevol.bsky.social set out to investigate polygenic footprints of microadaptation to altitude in the pine processionary moth. Instead we uncovered a strong oligogenic footprint of selection potentially underlying insecticide resistance... academic.oup.com/gbe/article/...

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Out today in @nature.com: our review on how single cells evolve into multicellular organisms. With Ozan Bozdag, @kaitong25.bsky.social, Peter Yunker, and @matthewherron.bsky.social. rdcu.be/9ZuiKow9twKa For an overview, check out the video below.

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Our paper on detecting (or not) balancing selection is now out, in all its typeset beauty, in the October issue of @molbioevol.bsky.social: academic.oup.com/mbe/article/...

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