Went to a wonderful GRC on 3dem and discovered a new GPCR structure!! It has alpha helical resolution and it's an inactive state

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Nature research paper: Diverse binding poses of agonistic neurotoxins on human Nav1.6 go.nature.com/4eApyjD

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New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo

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Take a look at our recent work! Happy to see the results of combining classical structural biology, cell-based work, and integrative modelling using cross-linking mass spectrometry (And I also had the opportunity to experiment with Blender to visualise our science a bit!)👇🏻

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ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

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